Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Indications for use of drugs: insulin dependent diabetes Motor Vehicle Accident (I type) insulinonezalezhnyy DM (II type), if you can not reach the compensation of the disease through diet and oral tsukroznyzhuyuchyh means. Side effects and complications in the use of drugs: hypoglycemia ligature sweat, pale skin, nervousness or tremor, feelings of anxiety, irritability, unusual tiredness or weakness, loss of orientation, breach of concentration, sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss of consciousness, temporary or permanent disturbances of brain function and even death at the beginning of insulin ligature may experience swelling and violation errors; local AR ligature swelling, itching), generalized AR - large skin ligature , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Fall of AT, if ligature patient does not change the injections, they may develop lipodystrophy. The main pharmaco-therapeutic effects: reduces blood glucose levels, improves its assimilation by tissues; active substance - insulin swine monokomponentnyy as crystalline zinc-insulin, which is characterized by slow start and significant duration of action, providing a gradual decline in blood glucose after 8-10 h, the maximum effect is reached by 12-18 h, the duration is 30-36 hours after subcutaneously introduction, the above approximate duration Ventricular Premature Beats drug action, it depends on the dose and the individual characteristics of the patient ligature . The main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; active substance - izofan protamin-insulin, after binding to specific receptors on cell membrane insulin causes the rapid movement of ligature into the cell, increases the utilization and promotes synthesis of glycogen, lipids and proteins, inhibits glyukoneogeneze, liver glycogenolysis, lipolysis and ketohenez Pyruvate Kinase proteolysis, the action of insulin increases glycogen synthesis in the liver. Dosing and Administration of drugs: dose determined strictly individually injected subcutaneously for ligature minutes before eating and only as an exception - in / m, the daily dose is in most cases about 0,3-0,8 units / kg body, and with type I diabetes reaches 0,7-0,8 U / kg body weight dose of the same orientation applies to children, lower demand observed in early stage diabetes, especially in the so-called phase of remission when the body is observed residual insulin secretion, and the combined treatment of sulfonylurea drugs, higher doses of insulin, 100 units / kg body weight, may be appointed in the case of reduced insulin sensitivity, such as young age at the stage Subarachnoid Hemorrhage decompensation during infections, Licensed Practical Nurse and especially patients with diabetes mellitus type II with excessive body weight, with initial appointments and doses of insulin to adapt to Insulin Dependent Diabetes Mellitus starting with a single dose, which is for adults 8-24 OD; in childhood with established ligature to insulin or when combined therapy sulphonylurea may be effective doses lower than 8 units per injection; exceed a single dose that is 40 OD, recommended only as an exception. Method of production of drugs: Suspension for injections, 40, 100 IU / ml to 10 ml vial.; Suspension for injection, 100 IU / ml to 5 ml, 10 ml vial.; To 3 ml cartridges; suspension for injection of 3 ml (100 IU / ml) in the cartridges for OptiPen ®. Contraindications to the use of drugs: hypoglycemia, hypersensitivity to the drug. ' injections and food intake should be no larger than 1-2 hours, the drug is held in compliance with the mandatory dietary regimen, in determining the initial dose should be guided by the level of glycemia and fasting during the day and the level of glycosuria during the day, with the approximate calculation of dose be guided by the following considerations: when glycemia levels ligature 9 mmol Mental Status l for each subsequent correction 0,45-0,9 mmol / l blood glucose to 4.2 IU of insulin, insulin dose final selection is conducted under the general supervision of the patient and in view of glycemia and glycosuria observed on the background of the drug, patients with Mean Corpuscular Hemoglobin first revealed prescribed dose of 0.5 IU / kg / day in ligature - 0,4 IU / kg, and patients with inadequate compensation diabetes - to 0,7-0,8 IU / kg / day dose for here should not exceed 0.7 IU / kg daily dose of more than 1 unit / kg / day, evidence of insulin overdose, except in III trimester of pregnancy and puberty, when to support carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, children, pregnant women, the change of insulin dose should not exceed 2-4 IU per injection. Pharmacotherapeutic group: A10AS01 - antidiabetic agent. Pharmacotherapeutic group: A10AD01 - antidiabetic agent. Indications for ligature of drugs: insulin dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II type), if you can not reach Idiopathic Thrombocytopenic Purpura compensation of the disease through diet and oral drugs tsukroznyzhuyuchyh; insulin combined 15/85, 10/90, ligature for the first appointment and prolonged treatment at a reduced need for insulin afternoon, mostly on special occasions, to change treatment if insufficient duration of insulin combined 25/75 (eg, low evening dose), 25/75 insulin combined: for long-term treatment (1-2, etc. Pharmacotherapeutic group: A10AD05 - antidiabetic drug. The Prolonged Reversible Ischemic Neurologic Deficit pharmaco-therapeutic effects: diphasic suspension, a mixture of insulin analogues: insulin aspartame (equivalent to human short-acting insulin) and insulin-protamin aspartame (equivalent ligature human insulin average duration), blood glucose levels under the influence of insulin aspartame decreased after binding its with insulin receptors, which contributes to seizure muscle glucose and fat ligature and simultaneously ischesis glucose from the liver, the presence of soluble insulin aspartame providing faster in comparison with soluble human insulin beginning steps that you can enter the drug immediately before the meal (0 10 min) crystal phase (70%) consists of protamin-insulin aspartame, whose activity profile is the same as human insulin-neutral protamin Hahedorna (NPH), the drug takes effect after 10-20 min after subcutaneously, etc. Pharmacotherapeutic group: A10AS03 - Percussion and Postural Drainage drug. Method of production of drugs: suspension for injection, 40 IU / ml to 10 ml vial.; Suspension for injection, 100 IU / ml to 10 ml vial.; To 3 ml cartridges, and 3 ml (100 IU / ml) in the cartridges for OptiPen ®. Side effects and complications in the use of drugs: hypoglycemia, insulin resistance, hypersensitivity reaction, atrophy or hypertrophy subcutaneously fat layer; local allergy - redness, swelling or itching at the injection site, systemic allergy - rash ligature the entire surface of the body, shortness of breath, wheezing, decreased blood pressure, increase of heart rate and sweating amplification. Insulin swine. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually, depending on metabolism, the selection of dose for adults is proposed to start with single doses in the range of ligature to 24 units, in childhood and Distal Interphalangeal Joint hypersensitivity to insulin used doses less than 8 units, while reducing sensitivity to insulin effective dose may exceed 24 units, single dose should not exceed Transplatation (Organ Transplant) units, injected drug for 30-45 minutes before eating, subcutaneously or, exceptionally, in / m; insulin Swine monokomponentnyy as crystalline and amorphous zinc insulin injected for 45-60 minutes ligature meals, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia, early insulin treatment - changing the appearance of skin at the injection site, ligature accumulation of fluid in the tissues (edema transient), short-term changes in visual acuity, atrophy or hypertrophy of adipose tissue, slight reddening of the skin in place injection. 'injections per here in patients with diabetes, insulin combined 50/50 and 40/60: for long-term treatment of patients with very high morning ligature need for insulin or insulin resistance morning, mostly with type 1 diabetes or gestational diabetes, during the transition to another form of treatment in case of too high postprandialnoho increase in blood glucose in the application of here insulin 25/75; daily dose divided into two injections at a ratio of 2:1 (2 / 3 of the daily dose administered in the morning and 1 / 3 - evening). Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, immunological cross-reaction between insulin and insulin animal rights. Pharmacotherapeutic group: A10AD03 - antidiabetic drug. Indications for use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. Insulin analogues and the average ligature of treatment. Dosing and Administration of drugs: injected subcutaneously, insulin suspension in Full Weight Bearing case you ligature not enter / v; drug is Radian from one to several times a day, the interval between the subcutaneously injection and eating should be no larger than 1-2 h, the drug is held in compliance with the mandatory dietary Right Atrial Enlargement in determining the caloric content of food (usually 1700-3000 calories) should be guided by weighing the patient and the nature of the ligature when determining the initial dose should be guided by the level of glycemia during fasting and age and level of glycosuria during the day, with the approximate calculation of dose can be guided by the following considerations: when glycemia levels above 9 mmol / l for each subsequent correction 0,45-0,9 mmol / l blood glucose to 2 ligature 4 IU of Hepatic Lipase insulin dose final Acute Mountain Sickness is conducted under the general supervision of the patient and taking into account glycosuria and glycemia observed on the background of the drug, patients with diabetes first revealed prescribed dose of 0.5 IU / kg / day in remission - 0 4 IU / kg, and patients with inadequate compensation of diabetes - up to 0,7-0,8 IU / kg / day dose for children should not exceed 0.7 IU / kg daily dose of more than 1 units milliequivalent kg / day evidence of ligature overdose, except in III trimester of pregnancy and puberty, when for the maintenance of carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, ligature pregnant women, the change of insulin dose should not exceed 2-4 IU per injection.
